Me and the wife did a US West Coast road trip years ago before we had kids.
We drove down 'Big Sur' and took in the beautiful scenery - it was amazing.
Being a bit of a golf nerd, I got very excited about doing the 17 mile drive and stopping at the world famous Pebble Beach golf club to take a few pics, visit the pro shop and have a few drinks in the club house - a true 'once in a lifetime' experience for me.
As we got closer to the exit I asked the wife to get the camera and check we had enough film (no digital in them days - good old fashioned 35mm roll) only to discover we'd left the camera in San Francisco
Of course I blamed her and she blamed me and it resulted in a massive argument that carried on for ages. I was trying to look out for the Pebble Beach/17 mile drive exit but was distracted by the wife constantly gobbing off at me.
It eventually dawned on me that we'd missed the exit and it was too late to turn back as we had to check-in at another hotel.
So not only did I miss Pebble Beach and will probably never get the chance again, but we also lost all of our photo's of SF and the Golden Gate bridge/Alcatraz etc.
Apart from that it was a great trip.