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filbertway

Coronavirus Thread

By filbertway, in General Chat

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StanSP

StanSP

Posted
Posted
13 minutes ago, yorkie1999 said:

So why identify it as something that's likely to cause alarm given the current situation in India.

Headline-maker. Gets the clicks doesn't it. 

SpacedX

SpacedX

Posted
Posted (edited)
1 hour ago, yorkie1999 said:

So why identify it as something that's likely to cause alarm given the current situation in India.

Evidence for greater transmissibility and escape from immunity is still circumstantial but provisional data indicates that it it may yet need to be upgraded to 'a variant of concern' and the fact that it carries the mutation L425R is significant. 

 

In spite of this, the Indian variant (B.1.617) has been around for some time which means actually it may not be as transmissible as the Kent/UK variant which proved so contagious last winter. Assuming that it has driven the current wave in India, it has taken several months to get to this point which would therefore suggest it’s likely less contagious than the Kent B.1.1.7 variant and that other factors are responsible- chiefly, poor hygiene, lack of testing, lax restrictions and control measures. 

 

It is currently 'a variant under investigation' because it has several mutations that are present in other variants of interest/concern or that have been shown to have antigenic escape in laboratory experiments. 

 

What concerns me about the Indian sub-continent is not necessarily the variant pre se, but the sheer spread of infection and the numbers.

 

To reiterate, worldwide, the more people that are infected the more likely cells will continue to mutate via changes to the spike protein which is the key the virus uses to unlock the doorway through what is known as the receptor-binding domain. This is where the spike makes first contact with the surface of our body's cells - for example, the angiotensin-converting enzyme 2, or ACE2 receptor. Any changes that make it easier for the virus to get inside are likely to give it an edge and prolong the global crisis.

 

Edited by Line-X
  • Like 1
yorkie1999

yorkie1999

Posted
Posted
3 minutes ago, Line-X said:

Evidence for greater transmissibility and escape from immunity is still circumstantial but provisional data indicates that it it may yet need to be upgraded to 'a variant of concern' and the fact that it carries the mutation L425R is significant. 

 

In spite of this, the Indian variant (B.1.617) has been around for some time which means actually it may not be as transmissible as the Kent/UK variant which proved so contagious last winter. Assuming that it has driven the current wave in India, it has taken several months to get to this point which would therefore suggest it’s likely less contagious than the Kent B.1.1.7 variant and that other factors are responsible- chiefly, poor hygiene, lack of testing, lax restrictions and control measures. 

 

It is currently 'a variant under investigation' because it has several mutations that are present in other variants of interest/concern or that have been shown to have antigenic escape in laboratory experiments. 

 

What concerns me about the Indian sub-continent is not necessarily the variant pre se, but the sheer spread of infection and the numbers.

 

To reiterate, worldwide, the more people that are infected the more likely cells will continue to mutate via changes to the spike protein which is the key the virus uses to unlock the doorway through what is known as the receptor-binding domain. This is where the spike makes first contact with the surface of our body's cells - for example, the angiotensin-converting enzyme 2, or ACE2 receptor. Any changes that make it easier for the virus to get inside are likely to give it an edge and prolong the global crisis.

 

Do you not think though, that this sort of information should be only for the eyes of the scientific community until it is established that it is any more/less contagious. Armed with all those letters and numbers you use, what is the average person going to do with that information...nothing, but the very fact it's been announced that we now have the Indian variant in Leicester, all that is going to do is spread panic because we have all witnessed what is going on in India and through simple name association, the public will now think we're going to end up burning our dead in the street. 

yorkie1999

yorkie1999

Posted
Posted
1 minute ago, Sol thewall Bamba said:

And in lots of other places in the UK as well, from that article:

 

"As of April 22, 132 cases of the Indian variant had been detected in the UK."

 

Not sure why the 3 cases in Leicester made the headline... 

Because Leicester is home to many Indians who have been returning home from India which sets up the next days headline "indians in Leicester fail to adhere to travel isolation"

SpacedX

SpacedX

Posted
Posted
9 minutes ago, yorkie1999 said:

Do you not think though, that this sort of information should be only for the eyes of the scientific community until it is established that it is any more/less contagious.

It is. I was simply adding some context.

 

12 minutes ago, yorkie1999 said:

but the very fact it's been announced that we now have the Indian variant in Leicester, all that is going to do is spread panic because we have all witnessed what is going on in India and through simple name association, the public will now think we're going to end up burning our dead in the street. 

The media are simply reporting what has been discovered - that's their job. Yes, as many have commented, the headline is designed to attract attention, but that's precisely what journalists are trained to do. When you actually read the article, it isn't scaremongering nor is it in the slightest bit sensationalised. It's also written for a lay audience.  

  • Like 1
Parafox

Parafox

Posted
Posted
3 hours ago, Line-X said:

Evidence for greater transmissibility and escape from immunity is still circumstantial but provisional data indicates that it it may yet need to be upgraded to 'a variant of concern' and the fact that it carries the mutation L425R is significant. 

 

In spite of this, the Indian variant (B.1.617) has been around for some time which means actually it may not be as transmissible as the Kent/UK variant which proved so contagious last winter. Assuming that it has driven the current wave in India, it has taken several months to get to this point which would therefore suggest it’s likely less contagious than the Kent B.1.1.7 variant and that other factors are responsible- chiefly, poor hygiene, lack of testing, lax restrictions and control measures. 

 

It is currently 'a variant under investigation' because it has several mutations that are present in other variants of interest/concern or that have been shown to have antigenic escape in laboratory experiments. 

 

What concerns me about the Indian sub-continent is not necessarily the variant pre se, but the sheer spread of infection and the numbers.

 

To reiterate, worldwide, the more people that are infected the more likely cells will continue to mutate via changes to the spike protein which is the key the virus uses to unlock the doorway through what is known as the receptor-binding domain. This is where the spike makes first contact with the surface of our body's cells - for example, the angiotensin-converting enzyme 2, or ACE2 receptor. Any changes that make it easier for the virus to get inside are likely to give it an edge and prolong the global crisis.

 

You make some very knowledgeable posts about this and I always read with interest. I'm just wondering what your expert field is as clearly, you know a lot about viral infection and transmission and the way your posts are set out suggests you must be in the fields of virology/immunology/research. 

Parafox

Parafox

Posted
Posted
2 hours ago, Line-X said:

It is. I was simply adding some context.

 

The media are simply reporting what has been discovered - that's their job. Yes, as many have commented, the headline is designed to attract attention, but that's precisely what journalists are trained to do. When you actually read the article, it isn't scaremongering nor is it in the slightest bit sensationalised. It's also written for a lay audience.  

So those with limited understanding of the true nature of this pandemic? There's probably a huge percentage of the public that will associate the stories with India and link them to the Indian population in Leicester who, to be fair, didn't do themselves any favours as the lockdowns progressed then eased. Inevitably there will be a reaction to these stories and the fact that Leicester was the first city to be independently locked down. I don't think the media want to create panic and, as you say, it's generally click-bait but there's bound to some element of reactionary responses.

Parafox

Parafox

Posted
Posted
Just now, Parafox said:

So those with limited understanding of the true nature of this pandemic? And you can't deny that the majority of those declining vaccination are from the sub-continent ethnic groups for whatever reasons.

There's probably a huge percentage of the public that will associate the stories with India and link them to the Indian population in Leicester who, to be fair, didn't do themselves any favours as the lockdowns progressed then eased. Inevitably there will be a reaction to these stories and the fact that Leicester was the first city to be independently locked down. I don't think the media want to create panic and, as you say, it's generally click-bait but there's bound to some element of reactionary responses.

 

SpacedX

SpacedX

Posted
Posted (edited)
13 minutes ago, Legend_in_blue said:

Roll on May 17th.  Masks are working wonders now.  

And will continue to do so in close quarters and indoors. 

Edited by Line-X
Tuna

Tuna

Posted
Posted
2 hours ago, Dr The Singh said:

He was great in kick boxer, but time cop stank

Hard Target was good as well.

Otis

Otis

Posted
Posted
2 hours ago, Sol thewall Bamba said:

So that's the 10pm curfew and now this that had zero scientific backing, just basically thrown out there on a whim. 

It's almost like they're making it up. 

  • Like 1
String fellow

String fellow

Posted
Posted

A new study has shown that the safest way for passengers to board a plane to minimise risk of Covid-19 propagation is window passengers first in random order, then aisle passengers again in random order, and elimination of the overhead stowage option. This contrasts with the theory that loading up from the rear frontwards is the safest way.

https://medicalxpress.com/news/2021-04-boarding-back-to-front-planes-covid-infection.html

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