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Posted (edited)
8 hours ago, Nuneatonfox in Manchester said:

I’m a layman so can only take this vaccine news at face value, but it’s the first time I’ve felt any sense of real optimism in all this.
 

However, I’m cautious of previous ‘game changers’ over the last few months that just fizzled out. Add to that the noise online - Reddit in particular where there is still a lot of negativity in terms of the sample size and logistics etc.

 

Its a strange feeling when it’s been all doom and gloom for close to a year now, but now I’m terrified of it being snatched away - it’s the hope that kills you!

Just about everyone on here is a "layman" in all of this and can only go on what the so-called experts say about things like this.

There is no doubt that potentially this is wonderful news but I thought Van Tam pretty much nailed where we are with this right now. As he said the safety analysis will come out in the next few days if this is all on track and then they will have to get apporoval for its use. I'm not sure where it is of if any doses have been manufactured in an large scale numbers yet but that will take time as will adiministering the vaccine and it will take 6 weeks for each vaccine to be fully effective.

There as yet some key unknowns, one of the prime one being how long does the vaccine remain effective? Will it be like the flu vaccine and be required every 12 months, will it be better than that or will it be just a few months in which case it will require regular re-vaccination of masses of people.

The real positive from yesterday was not only the good news itself of a possible successful vaccine but the fact that most of the other ones in development follow a similar method of attacking the virus meaning there is a chance we shall have more than one vaccine and this will be needed if we are to get the world back to some kind of normality.

The news also shows that the current approach is unfortunately the correct one. At least now there is a hope, if yet some months away, that we can avoid a fourth wave of this disease, though a smaller third one would appear possible, and, though I think social distancing to some degree will remain for quite  a while, by next summer things should look better if all goes well and it really does work as well as it seems it might.

 

Edited by reynard
  • Like 1
Posted
6 hours ago, Kopfkino said:

...

 

It’s fantastic news that Pfizer feel confident enough to put this out there, the light at the end of the tunnel is beginning to get brighter and highlights the folly of those content to sacrifice other people’s lives. I get the excitement to get rid of this shitshow but it should be bounded by ample caution.

It is fantastic news, and I am sure those associated with Pfizer were ecstatic to communicate the news, especially their shareholders. This mild cynicism in no way detracts from the sense of hope.
 

Chop chop Oxford.

Posted
4 hours ago, Bugg said:

I work in a supermarket and basically we're told that we can't refuse entry for people not wearing masks due to people potentially being exempt.

Also, supermarket staff take enough shit from customers over nothing so adding another reason to be abused really just isn't worth their time considering most are paid less than £10 an hour.

 

That's what security staff are for. Simple fact is, the supermarkets don't want to lose the custom.

Posted
2 minutes ago, Buce said:

 

That's what security staff are for. Simple fact is, the supermarkets don't want to lose the custom.

Security staff are usually nothing more than a deterrent, they aren’t bouncers. 


They also can’t stop people going in as they might have an exemption.

 

We are relying on people not being knobs, but the world is full of knobs. So we’ve now got “anxiety willy pullers” going round saying they don’t have to wear one. 

  • Like 4
Posted
1 minute ago, Babylon said:

Security staff are usually nothing more than a deterrent, they aren’t bouncers. 


They also can’t stop people going in as they might have an exemption.

 

We are relying on people not being knobs, but the world is full of knobs. So we’ve now got “anxiety willy pullers” going round saying they don’t have to wear one. 

I wonder if these same people would walk around without a scarf covering their face if it was -20 c into a biting wind ? 

Posted
6 minutes ago, Babylon said:

Security staff are usually nothing more than a deterrent, they aren’t bouncers. 


They also can’t stop people going in as they might have an exemption.

 

We are relying on people not being knobs, but the world is full of knobs. So we’ve now got “anxiety willy pullers” going round saying they don’t have to wear one. 

 

Not much of one, it would seem.

Posted

So far all the good news is based on the Pfizer announcement, a link to that is provided below.

 

https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-vaccine-candidate-against

 

This is the first of potentially several announcements as the 40+ Phase 3 clinical trials conclude.  We could possibly have several vaccines by the end of the year.

 

We still have to manage spread of the virus this Autumn and Winter.  Even if things move quickly the vaccination program will take several months, there are two vaccinations three weeks apart required and 90% immunity is only achieved one week after administration of the second vaccination.  So we have great news which means that by next summer we could have achieved herd immunity against this strain of Covid-19 and if the Denmark strain does not spread we can look forward to a more normal life next year.

  • Like 1
Posted
5 minutes ago, Crinklyfox said:

So far all the good news is based on the Pfizer announcement, a link to that is provided below.

 

https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-vaccine-candidate-against

 

This is the first of potentially several announcements as the 40+ Phase 3 clinical trials conclude.  We could possibly have several vaccines by the end of the year.

 

We still have to manage spread of the virus this Autumn and Winter.  Even if things move quickly the vaccination program will take several months, there are two vaccinations three weeks apart required and 90% immunity is only achieved one week after administration of the second vaccination.  So we have great news which means that by next summer we could have achieved herd immunity against this strain of Covid-19 and if the Denmark strain does not spread we can look forward to a more normal life next year.

I want to remain positive about this news, and in the main it is very positive, but I can't help but worry just how badly our Government will mess this up!

  • Like 1
Posted
7 hours ago, Kopfkino said:


The point with sample size isn’t the trial itself but the fact this is a preliminary analysis based on the first 94 to report developing Covid. In the 3 months the trial has been going, you’d expect a couple of % to get it, say 500 of the 22000 to get the placebo. Good place to be in 20% of the way through but no certainties yet.

 

Pfizer haven’t analysed the data yet, let alone released it for anyone else to look at and yet you have someone like John Bell, who should know better, saying that life will be back to normal in March. It might be but so far we’ve had one press release, it’s not quite sufficient to be making such grand statements.

 

It’s fantastic news that Pfizer feel confident enough to put this out there, the light at the end of the tunnel is beginning to get brighter and highlights the folly of those content to sacrifice other people’s lives. I get the excitement to get rid of this shitshow but it should be bounded by ample caution.

That was absolute insanity wasn't it? The path back to 'normality' is going to be a long and extremely cautious one. World leaders aren't suddenly going to stand on their platforms and declare everything back to normal and I would suggest stuff like masking is going to be around for a very long time. So while your pubs, clubs, gigs will be allowed to get going again, any hint of an outbreak and local PH teams are going to close them down asap. 

Posted

 

 

38 minutes ago, st albans fox said:

I wonder if these same people would walk around without a scarf covering their face if it was -20 c into a biting wind ? 

Of course they do, just like they wear halloween costumes without an inch of skin showing. A Facebook "Friend" was moaning about her anxiety and not able wear a mask, with her profile picture on Facebook being her in a mask for halloween. :doh:

 

She's also a "they are taking away our liberties" arse hole. Coincidence, no. 

  • Like 1
Posted
28 minutes ago, Crinklyfox said:

So far all the good news is based on the Pfizer announcement, a link to that is provided below.

 

https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-vaccine-candidate-against

 

This is the first of potentially several announcements as the 40+ Phase 3 clinical trials conclude.  We could possibly have several vaccines by the end of the year.

 

We still have to manage spread of the virus this Autumn and Winter.  Even if things move quickly the vaccination program will take several months, there are two vaccinations three weeks apart required and 90% immunity is only achieved one week after administration of the second vaccination.  So we have great news which means that by next summer we could have achieved herd immunity against this strain of Covid-19 and if the Denmark strain does not spread we can look forward to a more normal life next year.

Can't we just nuke Denmark? I'm sure we can all agree that's for the common good. 

  • Haha 2
Posted
8 hours ago, WigstonWanderer said:

That’s good, but let’s hope that it is accurate. The difference might be a bit subtle for the media. Was it an expert saying this?

Van-tam discussed precisely your point in the government briefing.  What they know is that 90% less people in the vaccine half of the trial showed symptoms than in the placebo side,   5 vs 90 or something.  
 

What he said they don’t know is whether the (presumed) 85 who were exposed but symptomless in the vaccine half were shedding virus and thus infective to others.

 

The trial conclusion is that it protects the individual from developing symptoms

( assumed to equate to more severe disease) - it is unknown at this stage whether it also prevents transmission between people exposed to the virus.

 

ideally it would do both, but even if it only does the former it can still be used to vaccinate vulnerable groups and minimise deaths and hospitalisations.
 


 

 

  • Thanks 1
Posted
8 minutes ago, Stivo said:

Van-tam discussed precisely your point in the government briefing.  What they know is that 90% less people in the vaccine half of the trial showed symptoms than in the placebo side,   5 vs 90 or something.  
 

What he said they don’t know is whether the (presumed) 85 who were exposed but symptomless in the vaccine half were shedding virus and thus infective to others.

 

The trial conclusion is that it protects the individual from developing symptoms

( assumed to equate to more severe disease) - it is unknown at this stage whether it also prevents transmission between people exposed to the virus.

 

ideally it would do both, but even if it only does the former it can still be used to vaccinate vulnerable groups and minimise deaths and hospitalisations.
 


 

 

Thanks for that. It is still good news of course if the vaccine does turn out to be 90% effective (after peer review). With that efficacy people will at least have the option to all but guarantee protection for themselves.

 

One more note of caution is that as far as I know they haven’t included vulnerable people in the trials, so it’s probably yet to be established whether for example elderly people develop immunity when vaccinated.

  • Like 1
Posted
2 hours ago, Babylon said:

Can't we just nuke Denmark? I'm sure we can all agree that's for the common good. 

 

Can't see a problem with that, but could we wait until Kasper returns from international duty over there?

  • Haha 4
Posted
2 hours ago, WigstonWanderer said:

Thanks for that. It is still good news of course if the vaccine does turn out to be 90% effective (after peer review). With that efficacy people will at least have the option to all but guarantee protection for themselves.

 

One more note of caution is that as far as I know they haven’t included vulnerable people in the trials, so it’s probably yet to be established whether for example elderly people develop immunity when vaccinated.

Not sure if you've seen this, but it seems positive in that an immune response is triggered in people of all ages - obviously a different vaccine but positive news.

 

https://www.aljazeera.com/news/2020/10/26/oxford-vaccine-prompts-immune-response-in-old-people-astrazeneca

  • Like 1
  • Thanks 1
Posted

My view on this virus has changed over the past few months, back in March/April I was sceptical. It has now ripped through our office, where now 6-7 people have tested positive for it. 

  • Like 1
Posted
21 minutes ago, filbertway said:

Not sure if you've seen this, but it seems positive in that an immune response is triggered in people of all ages - obviously a different vaccine but positive news.

 

https://www.aljazeera.com/news/2020/10/26/oxford-vaccine-prompts-immune-response-in-old-people-astrazeneca

With so many attempts at a vaccine, surely one of them at least will give everything we need.

  • Like 1
Posted
3 hours ago, Lionator said:

That was absolute insanity wasn't it? The path back to 'normality' is going to be a long and extremely cautious one.

Agree entirely.

 

3 hours ago, Lionator said:

World leaders aren't suddenly going to stand on their platforms and declare everything back to normal 

Unfortunately some will. Bolsonaro immediately springs to mind. 

Guest Harrydc
Posted
4 hours ago, Buce said:

 

That's what security staff are for. Simple fact is, the supermarkets don't want to lose the custom.

No.. It states on the government website that there are many exemptions, and you do not need proof for these exemptions. Therefore, it could be a discriminantry act for supermarkets to turn away people who say they are exempt. 

Posted
1 hour ago, Harrydc said:

No.. It states on the government website that there are many exemptions, and you do not need proof for these exemptions. Therefore, it could be a discriminantry act for supermarkets to turn away people who say they are exempt. 

 

Yeah, I get that this is yet another govt fvck up; relying on the British public not to behave like twats is never going to work.

 

As I have said before, if people want to claim exemption on medical grounds, they should require a doctor's note.

Posted
4 hours ago, Babylon said:

Can't we just nuke Denmark? I'm sure we can all agree that's for the common good. 

I’d be happy with this, in the hope a couple fall short and land in France.

  • Haha 1

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